Author

Z. Chong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. S. Diamond· 3 shared J. B. Case· 2 shared P. J. Halfmann· 2 shared S. Mackin· 2 shared Y. Kawaoka· 2 shared A. Carfi· 1 shared A. Jung· 1 shared A. K. Shum· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

M. S. Diamond

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

J. B. Case, S. Mackin, J. Errico, Z. Chong, E. A. Madden, B. Guarino, M. A. Schmid, K. Rosenthal, K. Ren, A. Jung, L. Droit, S. A. Handley, P. J. Halfmann, Y. Kawaoka, J. E. Crowe, , M. S. Diamond

This study evaluates the effectiveness of S309 and AZD7442 monoclonal antibodies against Omicron variants in mice, showing reduced lung infection despite decreased neutralization in vitro.

bioRxiv · Mar 17, 2022Microbiology

Boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibody responses and protection against B.1.1.529 infection in mice

B. Ying, S. M. Scheaffer, B. Whitener, C.-Y. Liang, O. Dmytrenko, S. Mackin, K. Wu, D. Lee, L. E. Avena, Z. Chong, J. B. Case, L. Ma, T. Kim, C. Sein, A. Woods, , M. S. Diamond

This study shows that boosting with Omicron-matched or historical mRNA vaccines increases neutralizing antibodies and protection against B.1.1.529 in mice, with the Omicron-matched booster showing slightly better outcomes.

bioRxiv · Feb 7, 2022 · PreprintMicrobiology

Nasally-delivered interferon-{lambda} protects mice against upper and lower respiratory tract infection of SARS-CoV-2 variants including Omicron

Z. Chong, C. E. Karl, P. J. Halfmann, Y. Kawaoka, E. S. Winkler, J. Yu, M. S. Diamond

This study shows that nasal delivery of IFN-λ protects mice against SARS-CoV-2 variants including Omicron in both upper and lower respiratory tracts without causing excessive inflammation.

bioRxiv · Jan 21, 2022 · PreprintMicrobiology

Mitochondrial Haplogroup Association with Fasting Glucose Response in African Americans Treated with a Thiazide Diuretic

B. A. Minniefield, N. Armstrong, V. Srinivasasainagendra, H. K. Tiwari, S. W. Ballinger, Z. Chong, S. Aslibekyan, D. Arnett, M. R. Irvin

The paper examines the association between mitochondrial haplogroups and fasting glucose response to thiazide diuretics in African Americans, finding small effects on glucose but not blood pressure.

bioRxiv · Oct 18, 2021Pharmacology & Toxicology

A defect in COPI-mediated transport of STING causes immune dysregulation in COPA syndrome

A. K. Shum, Z. Deng, Z. Chong, C. S. Law, K. Mukai, F. O. Ho, T. Martinu, B. J. Backes, W. L. Eckalbar, T. Taguchi

This study shows that defective COPI transport of STING due to COPA mutations leads to immune dysregulation and type I interferon signaling in COPA syndrome.

bioRxiv · May 20, 2020Immunology