Pharmacology & ToxicologybioRxiv
Interdependent allosteric FFA2R modulators synergistically induce functional selective activation and desensitization in neutrophils
S. Lind, A. Holdfeldt, J. Martensson…·C. Dahlgren
The paper shows two non-activating FFA2R allosteric modulators synergistically activate neutrophil NADPH-oxidase without triggering Ca2+ signaling.
DOI 10.1016/j.bbamcr.2020.118689