Ifnar1 signaling breaks the hepatic urea cycle to regulate adaptive immunity
A. Lercher, A. Bhattacharya, A. M. Popa, M. Caldera, M. F. Schlapansky, H. Baazim, P. Majek, J. S. Brunner, L. J. Kosack, D. Vitko, T. Pinter, B. Guertl, D. Reil, U. Kalinke, K. L. Bennett, , A. Bergthaler
This study shows that IFN-I signaling in the liver disrupts the urea cycle, reducing arginine and increasing ornithine, which suppresses CD8 T cell responses and improves liver pathology during viral infection.
bioRxiv · Sep 10, 2019 · PreprintImmunology