A. Bhattacharya

Heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans

This study shows that heat-killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide extend C. elegans lifespan by improving proteostasis and immune responses through modulation of insulin-like signaling, autophagy-lysosome pathway, and antioxidant defenses.

PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer

Rolipram inhibits hedgehog signaling by promoting ubiquitination and degradation of GLI2FL and GLI3FL, reducing GLI1 levels and tumor growth in breast cancer models.

The colocatome as a spatial -omic reveals shared microenvironment features between tumour-stroma assembloids and lung cancer specimens

The paper introduces the colocatome, a spatial-omic framework, to compare microenvironment features between tumour-stroma assembloids and lung cancer specimens, finding that fibroblasts protect cancer cells from treatment by reorganizing cytoarchitecture.

Gestures Of Hunger: Uncovering Intentional Gestural Communication In Free-Ranging Hanuman Langurs

This study identifies intentional gestural communication in Hanuman langurs, showing they use learned gestures to request food from humans and adapt this behavior as a foraging strategy.

Serine ubiquitination of p62 regulates Nrf2 dependent redox homeostasis

This study shows that serine ubiquitination of p62 by Legionella pneumophila SidE effectors inhibits Nrf2 signaling, altering redox homeostasis and host metabolism during infection.

TBC1D15 potentiates lysosomal regeneration from damaged membranes

The paper identifies TBC1D15 as a key regulator of lysosomal regeneration from damaged membranes through a pathway involving LIMP2, ATG8, and ALR components.

The FIGNL1-interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin.

The paper identifies C1orf112 as a synthetic lethal partner of PICH, showing it stabilizes FIGNL1 and regulates RAD51 retention on chromatin, impacting genome maintenance.

Amplicon structure creates collateral therapeutic vulnerability in cancer

The paper identifies DDX1 as a passenger gene co-amplified with MYCN in cancer, showing that its aberrant expression creates a therapeutic vulnerability through mTORC1 dependency.

Intrinsic disorder in CENP-ACse4 tail and its chaperone facilitates synergistic association for kinetochore stabilization

This study investigates the interaction between the disordered Cse4 N-tail and its chaperone Scm3, showing how their synergistic association facilitates kinetochore stabilization through electrostatic interactions and reduced disorder.

Evolution of constitutive bacteriocin production and release

This study uses a mathematical model to show that constitutive bacteriocin production can evolve without requiring competitor detection or suicidal toxin release.

Human anelloviruses produced by recombinant expression of synthetic genomes.

This paper demonstrates the production of human anelloviruses in vitro using synthetic genomes in MOLT-4 cells, showing infectivity in mice and enabling further virology studies.

Exceptions to the rule: Why does resistance evolution not undermine antibiotic therapy in all bacterial infections?

This study identifies factors explaining variation in antibiotic resistance across bacterial pathogens and drugs, finding nosocomial and indirectly transmitted pathogens have higher resistance prevalence.

Protein reservoirs of seeds are composites of amyloid and amyloid-like structures facilitating sustained release during germination and seedling growth

This study identifies amyloid and amyloid-like structures in plant seed storage protein bodies (SSPB) and demonstrates their role in controlling germination and seedling growth.

Transcriptomic analysis of ribosome biogenesis and pre-rRNA processing during growth stress in Entamoeba histolytica

The paper identifies ribosome biogenesis factors in Entamoeba histolytica and shows their differential regulation during stress, revealing unique features compared to yeast and humans.

Bacterial hopanoids: a newly identified potent inducer of monocyte to macrophage differentiation

This study identifies bacterial hopanoids as a potent inducer of monocyte to macrophage differentiation through structural and functional analyses.

The Fragile X Mental Retardation Protein protects the lung from xenobiotic stress by facilitating the Integrated Stress Response

This study shows FMRP protects lung cells from stress by enabling the Integrated Stress Response, with similar effects observed in mice and human cells.

Delineating the complex mechanistic interplay between autophagy and monocyte to macrophage differentiation: a functional perspective

This study investigates the role of autophagy in monocyte to macrophage differentiation, showing its critical role in sustaining the process and directing differentiation via protein degradation.

MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

This study shows MYC overexpression in TNBC reduces immune cell infiltration and interferon signaling, contributing to immune evasion and poor response to immunotherapy.

An mRNA expression-based signature for oncogene-induced replication-stress

The paper develops a six-gene expression signature to identify oncogene-induced replication stress in cancers, validated in breast cancer samples and applied across multiple tumor subtypes.

Analytical validation and performance characteristics of a 48-gene next-generation sequencing panel for detecting potentially actionable genomic alterations in myeloid neoplasms

The paper validates a 48-gene NGS panel for detecting actionable genomic mutations in myeloid neoplasms, showing high sensitivity and specificity.

Nuclear Morphology Optimized Deep Hybrid Learning (NUMODRIL): A novel architecture for accurate diagnosis/prognosis of Ovarian Cancer

This paper introduces a novel deep hybrid learning architecture, NUMODRIL, for classifying ovarian cancer tissues based on nuclear morphology and lamin protein distribution, achieving high accuracy and efficiency.

Altered food habits? Understanding the feeding preference of free-ranging Grey langur (Semnopithecus entellus) within an urban settlement.

This study examines the feeding preferences of free-ranging grey langurs in an urban setting, finding they prefer urban food items over natural ones due to resource scarcity and human interaction.

CD4+ T-cell epitope prediction by combined analysis of antigen conformational flexibility and peptide-MHCII binding affinity

The paper predicts CD4+ T-cell epitopes by combining antigen conformational flexibility and peptide-MHCII binding affinity, achieving 40% accuracy in epitope prediction.

Origin of a novel CYP20A1 transcript isoform through multiple Alu exaptations creates a potential miRNA sponge

The paper identifies a novel CYP20A1 transcript isoform generated by Alu exaptation that functions as a miRNA sponge in human neurons.

Evaluation of modulators of cAMP-response in terms of their impact on cell cycle and mitochondrial activity of Leishmania donovani

This study evaluates cAMP modulators' effects on Leishmania donovani proliferation, cell cycle, and mitochondrial activity, identifying etazolate as a potent anti-leishmanial agent.

A comprehensive and comparative study on the action of pentacyclic triterpenoids on Vibrio cholerae biofilms.

This study evaluates the antibiofilm effects of three pentacyclic triterpenoids on V. cholerae biofilms, revealing their impact on biofilm formation, structure, and interactions with quorum sensing systems.

A longitudinal study of perceived stress and cortisol responses in an undergraduate student population from India

This study examines stress and cortisol responses in Indian undergraduate students over a year, finding sex differences in cortisol levels and stress adaptation.

Histone chaperone Nucleophosmin regulates transcription of key genes involved in oral tumorigenesis.

This study shows that acetylated NPM1 coactivates transcription at promoters and enhancers, regulating genes involved in oral cancer progression.

Can Living with an Alien Invasive Fish, Tilapia, Influence the Shoaling Decision-Making and Exploratory Behaviour of an Air-Breathing Freshwater Fish, the Climbing Perch?

This study examines how exposure to invasive tilapia affects the social decision-making and exploratory behavior of climbing perch, finding no significant changes in preference or boldness.

A framework for transcriptome-wide association studies in breast cancer in diverse study populations

This paper develops a framework for transcriptome-wide association studies (TWAS) in breast cancer across diverse populations, identifying gene associations in underrepresented groups that are missed by GWAS.