Author

J. S. Brunner

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Immunology· 1

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Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Bergthaler· 1 shared A. Bhattacharya· 1 shared A. Lercher· 1 shared A. M. Popa· 1 shared B. Guertl· 1 shared D. Reil· 1 shared D. Vitko· 1 shared G. Schabbauer· 1 shared

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2019-2019 · peak 1/yr

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1 shared paperImmunology

A. Bergthaler

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1 paper

Recent·Most cited

ImmunologybioRxivPreprintSep 10, 2019

Ifnar1 signaling breaks the hepatic urea cycle to regulate adaptive immunity

A. Lercher, A. Bhattacharya, A. M. Popa…·A. Bergthaler

This study shows that IFN-I signaling in the liver disrupts the urea cycle, reducing arginine and increasing ornithine, which suppresses CD8 T cell responses and improves liver pathology during viral infection.

DOI 10.1101/762310

mousebulk RNA-seq

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