Tempered IL-2 Signals Program PD-1 Checkpoint Blockade-Responsive Stem-like Exhausted T Cells During Priming
V. Kalia, J. Reed, A. Khanna, R. Toumi, H. Xiao, T. Pulliam, R. Deo, P. Nghiem, S. Sarkar
This study shows that tempered IL-2 signals promote the development of PD-1 checkpoint blockade-responsive stem-like exhausted CD8 T cells during priming, while strong IL-2 signals drive terminal differentiation.
bioRxiv · May 25, 2023 · PreprintImmunology