A. Khanna

The SET1 protein of Leishmania donovani moderates the parasite's response to a hostile oxidative environment

This study investigates the role of LdSET1 in Leishmania donovani, finding it moderates the parasite's response to oxidative stress in host macrophages, enabling infection persistence without host cell eradication.

IFNγ modestly contributes to disease progression in the Ndufs4(-/-) model of Leigh syndrome while IP10 is dispensable

Tempered IL-2 Signals Program PD-1 Checkpoint Blockade-Responsive Stem-like Exhausted T Cells During Priming

This study shows that tempered IL-2 signals promote the development of PD-1 checkpoint blockade-responsive stem-like exhausted CD8 T cells during priming, while strong IL-2 signals drive terminal differentiation.

Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4(KO) model of Leigh syndrome

This study shows that peripheral macrophages contribute to CNS lesions in the Ndufs4(-/-) Leigh syndrome model, despite microglia depletion having limited effect.

Enhanced donor antigen presentation by B-cells predicts acute cellular rejection and late outcomes after transplantation.

The paper shows that a higher antigen presenting index (API) in B-cells predicts acute rejection and poor long-term outcomes after liver or intestine transplantation.

An Automated Pipeline for Differential Cell Counts on Whole-Slide Bone Marrow Aspirate Smears

This paper develops an automated machine learning pipeline for differential cell counts on whole-slide bone marrow aspirate smears, showing high concordance with manual counts and reduced intra-slide variance.

U2AF1 is a haplo-essential gene required for cancer cell survival

This study shows that U2AF1 is a haplo-essential gene for cancer cell survival, as mutant cells depend on residual wild-type U2AF1 for viability and are sensitive to its reduction.

Impaired T-cell and antibody immunity after COVID-19 infection in chronically immunosuppressed transplant recipients

This study evaluates T-cell and antibody immunity to SARS-CoV-2 in transplant recipients, finding impaired responses and increased CMV co-infection risk post-infection.

Simplified Molecular Classification of Lung Adenocarcinomas Based on EGFR, KRAS, and TP53 Mutations

This paper classifies lung adenocarcinomas into six subtypes based on EGFR, KRAS, and TP53 mutations, finding associations with prognosis and validating the classification against clinical outcomes.