Pharmacologic activation of G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma
C. A. Natale, J. Li, T. Dentchev, B. Capell, J. Seykora, B. Stanger, T. Ridky
This study shows that activating the GPER receptor with G-1 inhibits PDAC growth, reduces c-Myc and PD-L1, and enhances immunotherapy response in mouse models and human tumors.
bioRxiv · Apr 13, 2019Cancer Biology