B. Stanger

Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells

This study shows that metabolic activity in cancer cells affects circadian rhythms, with hypermetabolic states linked to weaker circadian oscillations in both mouse and human tumor cells.

Physiological reprogramming in vivo mediated by Sox4 pioneer factor activity

This study shows Sox4 initiates hepatobiliary metaplasia by first closing hepatocyte enhancers and then opening biliary enhancers in adult liver cells.

p53 restoration in small cell lung cancer identifies a latent Cyclophilin-dependent necrosis mechanism

This study shows that p53 restoration in SCLC can induce necrosis via cyclophilin-dependent mechanisms, revealing subtype-specific responses and potential therapeutic targets.

Rapid in vivo multiplexed editing (RIME) of the adult mouse liver

This paper introduces RIME, a method for rapid in vivo gene editing in adult mouse liver, demonstrating efficient knockout of multiple genes.

MYC controls metastatic heterogeneity in pancreatic cancer

This study identifies MYC as a key driver of metastatic heterogeneity in pancreatic cancer by linking its activity to increased metastasis through TAM recruitment.

Dissecting phenotypic transitions in metastatic disease via photoconversion-based isolation

This paper introduces PIC-IT, a photoconversion-based technique to isolate spatially distinct tumor cells, revealing phenotypic heterogeneity and NF-κB/AP-1 signaling enrichment in disseminated tumor cells.

Pharmacologic activation of G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma

This study shows that activating the GPER receptor with G-1 inhibits PDAC growth, reduces c-Myc and PD-L1, and enhances immunotherapy response in mouse models and human tumors.