A Bistable Mechanism Mediated by Integrins Controls Mechanotaxis of Leukocytes
A. Hornung, T. Sbarrato, N. Garcia-Seyda, L. Aoun, X. Luo, M. Biarnes-Pelicot, O. Theodoly, M.-P. Valignat
The paper shows that leukocytes use a bistable mechanism involving integrins LFA-1 and VLA-4 to decide their direction in response to flow.
bioRxiv · Dec 31, 2018Biophysics