Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease
M. Mendiratta, M. Mendiratta, S. K. Ganguly, S. Rai, R. Gupta, L. Kumar, S. Bakhshi, V. Dadhwal, D. Pushpam, P. S. Malik, R. Pramanik, M. Aggarwal, A. K. Gupta, R. Dhawan, T. Seth, , R. K. Sahoo
This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.
bioRxiv · Apr 11, 2024 · PreprintImmunology