L. Kumar

Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease

This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.

Unveiling Vaginal Fibrosis: A Novel Murine Model Using Bleomycin and Epithelial Disruption

This study develops a murine vaginal fibrosis model using bleomycin and epithelial disruption, showing fibrosis at 3 weeks with resolution by 6 weeks.

SARS-CoV-2 spike antibodies cross-react with dengue virus and enhance infection in vitro and in vivo

The paper shows that SARS-CoV-2 spike antibodies can enhance DENV2 infection in vitro and in vivo, suggesting potential for increased dengue severity in COVID-19 survivors.

Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substrate-dependent virtual screening

This paper quantifies allosteric communications in MMP1 on alpha-synuclein aggregates using FRET and virtual screening, showing substrate-dependent changes in ligand-binding sites.

Inter-domain dynamics and fibrinolytic activity of matrix metalloprotease-1

This study investigates how inter-domain dynamics of MMP1 correlate with its fibrinolytic activity using single-molecule FRET and kinetic modeling.

Allosteric communications between domains modulate activity of matrix metalloprotease-1

This paper identifies functionally relevant inter-domain dynamics in MMP1 on collagen fibrils, showing that open conformations correlate with activity and can be modulated by mutations and ligands.

Cephalosporins target quorum sensing and suppress virulence of Pseudomonas aeruginosa in Caenorhabditis elegans infection model

This study shows cephalosporins inhibit quorum sensing and virulence in Pseudomonas aeruginosa, improving survival in C. elegans.

Global cropland connectivity: A risk factor for invasion and saturation by emerging pathogens and pests

The paper assesses global cropland connectivity networks for key crops to identify high-risk areas for pathogen and pest spread, integrating this with other factors for pest risk assessment.

Sensory domain of the cell cycle kinase CckA in Caulobacter crescentus regulates the differential DNA binding activity of the master regulator CtrA

The paper identifies a mutation in CckA's PAS-B domain that increases CtrA phosphorylation but selectively enhances its binding to the origin of replication, Cori, in Caulobacter crescentus.