R. Gupta

Biomolecular Condensates Can Enhance Homotypic RNA Clustering

This study shows that repeat RNAs form nanoscale clusters within biomolecular condensates, driven by sequence features and RNA secondary structure, and that G3BP1 buffers these interactions.

Spatial mapping reveals unique cellular interactions and enhanced tertiary lymphoid structures in responders to anti-PD-1 therapy in mucosal head and neck cancers.

The paper identifies immune landscape differences in responders and non-responders to anti-PD-1 therapy in head and neck cancers using spatial mapping.

Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease

This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.

Dynamic Adaptation in Extant Porins Facilitates Antibiotic Tolerance in Energetic Escherichia coli

This study identifies a mechanism by which Escherichia coli tolerate antibiotics through dynamic porin inhibition, independent of gene expression, involving electrostatic modifications.

TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport

The paper identifies TDP43 aggregation at ER-exit sites as a cause of impaired ER-to-Golgi transport in ALS.

Genomes of Aegilops umbellulata provide new insights into unique structural variations and genetic diversity in the U-genome for wheat improvement

This study presents a high-quality genome assembly of Ae. umbellulata and resequencing data revealing structural variations, evolutionary sub-populations, and new resistance gene haplotypes useful for wheat improvement.

Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression

The paper shows that expressing a heterologous squalene synthase from Pseudogymnoascus destructans in Aspergillus nidulans alters terpene biosynthesis, increasing squalene and new nidulenes while reducing austinol.

A novel glideosome-associated protein S14 coordinates sporozoite gliding motility and infectivity in mosquito and mammalian hosts

The Endosomal pH Regulator NHE6 is Required for Insulin-Stimulated Glucose Uptake in Adipocytes

This study shows that NHE6 is essential for insulin-stimulated glucose uptake in adipocytes by regulating GLUT4 trafficking and expression.

Identification of leaf rust resistance loci in a geographically diverse panel of wheat using genome-wide association analysis

This study identifies leaf rust resistance loci in wheat using GWAS, finding 27 marker-trait associations, 20 near known resistance genes and 7 potentially novel regions.

Photonic-Plasmonic Coupling Enhanced Fluorescence Enabling Digital-Resolution Ultrasensitive Protein Detection

This paper enhances fluorescence detection using photonic-plasmonic coupling, achieving ultrasensitive protein detection with a 52-fold signal boost and 10 fg/ml detection limit.

Pleiotropic roles for mycobacterial DinB2 in frameshift and substitution mutagenesis

This study investigates the mutagenic roles of mycobacterial DinB2, showing it drives substitution and frameshift mutations, and becomes more mutagenic with manganese.

Neuronal Maturation-dependent Nano-Neuro Interaction and Modulation

This study investigates nano-neuro interactions during neural network maturation, finding that nanoparticle density correlates with neuronal maturation stage and results in heterogeneous optical neuromodulation.

Immunity priming uncouples the growth-defense tradeoff in tomato

This study shows that immunity priming in tomato can uncouple the growth-defense tradeoff, allowing for disease resistance without compromising growth.

Small molecule mediated stabilization of PP2A modulates the Homologous Recombination pathway and potentiates DNA damage-induced cell death

This study shows that stabilizing PP2A with a small molecule enhances DNA damage-induced apoptosis in HGSC cells and xenografts, both alone and with PARPi, by inhibiting HR and targeting RAD51.

High-dimensional and spatial analysis reveals immune landscape dependent progression in cutaneous squamous cell carcinoma

This study compares immune landscapes of non-progressing and progressing cutaneous squamous cell carcinomas to identify immune features associated with metastasis.

TOR coordinates Cytokinin and Gibberellin signals mediating development and defense

This study shows TOR coordinates cytokinin and gibberellin signals to regulate plant development and defense, with differential effects based on developmental status and hormone ratios.

Uneven terrain treadmill walking in younger and older adults

This study tests how varying treadmill terrain unevenness affects gait kinematic variability and perceived stability in younger and older adults.

Elucidating Collective Translocation of Nanoparticles Across the Skin Lipid Barrier: A Molecular Dynamics Study

This study uses molecular dynamics simulations to examine nanoparticle translocation through skin lipid membranes, finding coated nanoparticles more efficiently traverse double bilayer models than bare particles.

Cytokinin regulates energy utilization in Botrytis cinerea

This paper shows cytokinin promotes energy consumption and glycolysis in Botrytis cinerea, with effects dependent on nutrient availability.

Evaluation of Correlation between CD44, Radiotherapy Response and Survival Rate in Patients with Advanced Stage of Head and Neck Squamous Cell Carcinoma (HNSCC)

Reovirus sensitizes microsatellite stable colorectal cancer to anti-PD-1 treatment via cross-talk in innate and adaptive immune systems

This study shows that reovirus enhances anti-PD-1 treatment effectiveness in microsatellite stable colorectal cancer by modulating innate and adaptive immune responses.

Bone-Specific Enhancement of Antibody Therapy for Breast Cancer Metastasis to Bone

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

Experimental safety testing shows that the NSAID tolfenamic acid is not toxic to Gyps vultures in India at concentrations likely to be encountered in cattle carcasses

The paper tests tolfenamic acid's toxicity to Gyps vultures and finds it safe at concentrations found in cattle carcasses, unlike other NSAIDs.

Cytokinin- microbiome interactions regulate developmental functions

This study shows that cytokinin (CK) influences phyllosphere microbiome composition and developmental functions in tomato, with CK-rich genotypes maintaining microbial diversity and promoting plant growth.

Direct acetylation of the conserved threonine of an immune regulator by bacterial effectors activates RPM1-dependent immunity in Arabidopsis

This study shows that bacterial acetyltransferase effectors directly acetylate RIN4 T166, activating RPM1-dependent immunity in Arabidopsis, and that SOBER1 suppresses this by deacetylating the same residue.

Fate trajectories of CD8+ T cells in chronic LCMV infection

This study uses scRNA-seq to analyze CD8+ T cell fate trajectories during chronic LCMV infection, identifying a branching point where cells commit to exhausted or memory-like lineages.

Recapitulating tumor microenvironment using preclinical 3D tissueoids model for accelerating cancer research and drug screening

This study develops a 3D tissueoids model using the AXTEX-4D platform to better simulate tumor microenvironment and drug resistance compared to 2D and collagen-based 3D systems.

AXTEX-4D™: A Novel 3D ex vivo platform for preclinical investigations of immunotherapy agents

The paper introduces AXTEX-4D, a 3D ex vivo platform for testing immunotherapy drugs by mimicking the tumor microenvironment to assess immune cell responses and drug efficacy.

Cytokinin inhibits fungal development and virulence by targeting cellular trafficking

This study shows cytokinin inhibits fungal growth and virulence by disrupting cell cycle, cytoskeleton, and endocytic trafficking in Botrytis cinerea and other phytopathogenic fungi.