Developmental chromatin programs determine oncogenic competence in melanoma
A. Baggiolini, S. J. Callahan, T. Trieu, M. M. Tagore, E. Montal, J. M. Weiss, S. E. Tischfield, Y. Fan, N. R. Campbell, N. Saurat, T. Hollmann, T. Simon-Vermot, S. K. Tickoo, B. S. Taylor, R. Koche, , R. M. White
The paper shows that BRAFV600E transforming ability depends on the cell of origin's transcriptional program, with neural crest and melanoblasts being more susceptible due to higher chromatin modifying enzyme expression and ATAD2-SOX10 complex formation.
bioRxiv · May 9, 2020Cancer Biology