L. Studer

A robust and inducible precise genome editing via an all-in-one prime editor in human pluripotent stem cells

This paper develops an inducible prime editing system in human pluripotent stem cells that enables efficient and controllable multiplex genome editing.

Identifying novel age-modulating compounds and quantifying cellular aging using novel computational framework for evaluating transcriptional age

The paper introduces RNAge, a transcriptional age score, to quantify cellular aging and identify age-modulating compounds in hPSC-derived cells.

Suppression of ferroptosis by vitamin A or antioxidants is essential for neuronal development

This study shows that suppressing ferroptosis via antioxidants or vitamin A is necessary for proper neuronal development and laminar organization in cortical organoids.

Lipid droplets are a metabolic vulnerability in melanoma

This study identifies lipid droplets as a metabolic vulnerability in melanoma by linking the pigmented cell state to increased fatty acid uptake and oxidative metabolism.

Electrical activity between skin cells regulates melanoma initiation

The paper shows GABAergic signaling between keratinocytes and melanoma cells promotes melanoma initiation via BRAFV600E, with electrical activity regulating oncogenic competence.

Anatomic position determines oncogenic specificity in melanoma

The paper shows that anatomic position influences oncogenic specificity in melanoma by identifying position-specific gene programs that interact with oncogenes like CRKL.

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

This study shows that chromosomal imbalances in hESCs provide a proliferative advantage under replicative stress, similar to cancer cells.

Developmental chromatin programs determine oncogenic competence in melanoma

The paper shows that BRAFV600E transforming ability depends on the cell of origin's transcriptional program, with neural crest and melanoblasts being more susceptible due to higher chromatin modifying enzyme expression and ATAD2-SOX10 complex formation.

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)

The paper introduces TEAZ, a method to rapidly model cancer in zebrafish by delivering gene constructs to specific cells, enabling faster tumor development and tracking.