BiochemistrybioRxivPreprint
Exosite inhibition of A Disintegrin And Metalloproteinase with Thrombospondin motif (ADAMTS)-5 by a glycoconjugated arylsulfonamide
S. Santamaria, D. Cuffaro, E. Nuti…·J. Ahnstroem
This study identifies an exosite on ADAMTS-5 as a target for selective inhibitors, demonstrating that binding to this site improves selectivity over active site targeting.
DOI 10.1101/2020.06.12.146324