ImmunologybioRxivPreprint
IL-1α secreted by subcapsular sinus macrophages promotes melanoma metastasis in the sentinel lymph node by upregulating STAT3 signaling in the tumor.
T. Virgilio, J. Bordini, G. Sartori…·S. F. Gonzalez
This study shows that IL-1α from subcapsular sinus macrophages promotes melanoma metastasis by enhancing STAT3 signaling in tumor cells, and blocking this pathway reduces metastasis.
DOI 10.1101/2021.10.11.463954