D. Morone

SEC62 and TMX4 control asymmetric autophagy of the nuclear envelope upon LINC complex disassembly

The paper identifies SEC62 and TMX4 as regulators of asymmetric autophagy of the nuclear envelope during LINC complex disassembly in response to ER homeostatic changes.

ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

The paper identifies monoclonal antibodies that neutralize multiple coronaviruses by targeting the fusion peptide, which becomes exposed upon ACE2 engagement.

IL-1α secreted by subcapsular sinus macrophages promotes melanoma metastasis in the sentinel lymph node by upregulating STAT3 signaling in the tumor.

This study shows that IL-1α from subcapsular sinus macrophages promotes melanoma metastasis by enhancing STAT3 signaling in tumor cells, and blocking this pathway reduces metastasis.

Extracellular Vesicles Hijack the Autophagic Pathway to Induce Tau Accumulation in Endolysosomes

This study shows extracellular vesicles deliver Tau seeds to endolysosomes, where autophagy promotes Tau accumulation and cytotoxicity, suggesting autophagy stimulation may worsen tauopathies.