T. Warne

Multimodal intrinsic activation of GPCRs in ultrastable plasma membrane nanodomains

This paper quantifies GPCR intrinsic activation at the plasma membrane, revealing spatial multimodality with most receptors showing negligible spontaneous activation.

Molecular basis for high affinity agonist binding in GPCRs

The paper determines active-state structures of β1AR bound to agonists and identifies structural changes that increase agonist affinity.