Cancer BiologybioRxiv
Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer
A. Shinde, T. Wilmanski, H. Chen…·M. Wendt
This study shows that pyruvate carboxylase (PC) is critical for pulmonary metastasis of breast cancer, as its depletion reduces lung metastasis without affecting primary tumor growth.
DOI 10.1186/s13058-018-1008-9