M. Wendt

Application of an integrated computational antibody engineering platform to design SARS-CoV-2 neutralizers

The paper designs SARS-CoV-2 neutralizing antibodies using a computational platform to improve binding affinity and developability, and introduces trispecific formats and Fc modifications to enhance efficacy and reduce risk.

Transglutaminase-2 facilitates extracellular vesicle-mediated establishment of the metastatic niche

This study identifies TGM2 as a key factor in metastatic niche formation via extracellular vesicles in breast cancer, showing its role in enhancing metastasis through fibronectin crosslinking.

Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy

This study shows that FGFR1 promotes T-DM1 resistance and tumor recurrence in HER2+ breast cancer, suggesting FGFR inhibitors like FIIN4 could be combined with T-DM1 for better treatment.

Biased signaling downstream of epidermal growth factor receptor regulates proliferative versus apoptotic response to ligand

This paper shows that in metastatic breast cancer, EGFR signaling is biased toward STAT1, leading to apoptosis, and that pharmacological biasing can enhance this effect.

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer

This study shows that pyruvate carboxylase (PC) is critical for pulmonary metastasis of breast cancer, as its depletion reduces lung metastasis without affecting primary tumor growth.