Author

D. Teegarden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

H. Chen· 2 shared A. J. Pfeil· 1 shared A. Shinde· 1 shared E. K. Cotul· 1 shared E. N. Devericks· 1 shared M. F. Coleman· 1 shared M. K. Wendt· 1 shared M. Safdar· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

H. Chen

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2 papers

Recent·Most cited

Hypoxia-mediated suppression of pyruvate carboxylase drives tumor microenvironment immunosuppression

M. F. Coleman, E. K. Cotul, A. J. Pfeil, E. N. Devericks, H. Chen, V. A. Kiesel, M. Safdar, D. Teegarden, S. D. Hursting, M. K. Wendt

This study shows that hypoxia suppresses pyruvate carboxylase (PC) in tumors, leading to increased lactate production and immunosuppression in the tumor microenvironment.

bioRxiv · Apr 6, 2022 · PreprintCancer Biology

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer

A. Shinde, T. Wilmanski, H. Chen, D. Teegarden, M. Wendt

This study shows that pyruvate carboxylase (PC) is critical for pulmonary metastasis of breast cancer, as its depletion reduces lung metastasis without affecting primary tumor growth.

bioRxiv · May 15, 2018Cancer Biology