Systems BiologybioRxivPreprint
Origins of cell-to-cell variability, kinetic proof-reading and the robustness of MAPK signal transduction
Sarah Filippi, Chris P. Barnes, Paul Kirk…·Michael P.H. Stumpf
The paper measures cell-to-cell variability in MAPK signaling and shows upstream noise drives ERK phosphorylation heterogeneity, with the system using kinetic proof-reading to robustly transmit signals.
DOI 10.1101/021790