Author

Takashi Irie

Hiroshima University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Akatsuki SaitoiD· 2 shared Alfredo A. HinayiD· 2 shared Arnon PlianchaisukiD· 2 shared Ayaka SakamotoiD· 2 shared Chihiro MotozonoiD· 2 shared Hayato ItoiD· 2 shared Hirofumi SawaiD· 2 shared Hiroki Futatsusako· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Akatsuki SaitoORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

A non-spike nucleocapsid R204P mutation in SARS-CoV-2 Omicron XEC enhances inflammation and pathogenicity

Shuhei Tsujino, Masumi Tsuda, Sayaka Deguchi, Jumpei Ito, Taha Y. Taha, Hesham Nasser, Lei Wang, Julia Rosecrans, Rigel Suzuki, Saori Suzuki, Kumiko Yoshimatsu, Mélanie Ott, Terumasa Ikeda, Kei Sato, Kazuo Takayama, , Miki Kawano

This study identifies the non-spike R204P mutation in the SARS-CoV-2 Omicron XEC variant as a driver of increased inflammation and pathogenicity through NF-κB activation.

Nature Communications · Dec 14, 2025Peer-reviewedMicrobiology

A Protein Language Model for Exploring Viral Fitness Landscapes

Jumpei Ito, Adam Patrick Strange, Wei Liu, Gustav Joas, Spyros Lytras, Keita Matsuno, Naganori Nao, Hirofumi Sawa, Keita Mizuma, Isshu Kojima, Jingshu Li, Tomoya Tsubo, Shinya Tanaka, Masumi Tsuda, Lei Wang, , Kei Sato

This paper introduces CoVFit, a protein language model that predicts SARS-CoV-2 variant fitness using spike protein sequences, identifying fitness-enhancing mutations and predicting emerging variants.

Nature Communications · May 13, 2025Peer-reviewedMicrobiology

Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke

Takashi Irie, Taito Matsuda, Yoshinori Hayashi, Kanae Matsuda‐Ito, Akihide Kamiya, Takahiro Masuda, Marco Prinz, Noriko Isobe, Jun‐ichi Kira, Kinichi Nakashima

This study converts microglia/macrophages into neurons in the injured brain to restore neurological function after stroke.

Proceedings of the National Academy of Sciences · Oct 9, 2023Peer-reviewedNeuroscience