Cancer BiologybioRxivPreprint
Synergistic effects of PARP inhibitors by Schlafen 11 and BRCA2-deficiency through accumulation of single-strand DNA gaps behind a fork
Hiroshi Onji, Sota Tate, Tomohisa Sakaue…·Junko Murai
This paper shows that SLFN11 and BRCA2-deficiency together increase PARP inhibitor sensitivity by enhancing ssDNA gap accumulation behind replication forks.
DOI 10.1101/2023.06.28.546820