Targeting acetyl-CoA metabolism attenuates the formation of fear memories through reduced activity-dependent histone acetylation
Desi C. Alexander, Tanya S. Corman, Mariel R. Mendoza, Andrew Glass, Tal Belity, Ranran Wu, Rianne R. Campbell, Joseph Han, Ashley A. Keiser, Jeffrey D. Winkler, Marcelo A. Wood, Thomas Kim, Benjamin Aaron Garcia, Hagit Cohen, Philipp Mews, , Shelley L. Berger
This study shows that inhibiting Acss2 reduces fear memory formation and anxiety in mice and rats by decreasing histone acetylation and gene expression in the hippocampus.
Proceedings of the National Academy of Sciences · Aug 3, 2022Peer-reviewedNeuroscience