Shelley L. Berger

This study identifies age-associated repression of HNF4α as a driver of liver metabolic dysfunction and shows that restoring HNF4α can reverse some age-related liver defects.

This study expands the HIF-2α proteomic interactome using TurboID proximity labeling, identifying 329 novel interactors and linking some to poor patient survival in breast cancer.

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.

The paper identifies SWING regions as chromatin domains that mediate gene regulation through interactions with nuclear speckles and the lamina, showing their role in development and disease.

This study identifies how histone modifications regulate gene expression in memory and exhausted CD8 T cells, revealing distinct epigenetic programs between these cell types.

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

This study shows that Acss2 knockout mice consume less alcohol and exhibit epigenetic and transcriptional changes in the ventral striatum, particularly in males.

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

The paper identifies neuropeptides that specify and reprogram division of labor in leafcutter ants, showing their role in behavior and transcriptomic changes.

The paper investigates chromatin conformation changes in Alzheimer's disease, finding loss of genomic loops and CTCF dysfunction linked to neurodegeneration.

This study shows ACSS2-mediated histone acetylation is critical for learning and memory in a mouse AD model, with acetate supplementation rescuing deficits.

This study identifies NUCKS1 as a novel SIRT7 interactor that promotes chromatin binding during senescence and liver aging, leading to metabolic and inflammatory gene expression.

The paper investigates how reducing histone acetylation in Alzheimer's disease models affects amyloid-reducing pathways and amyloid-beta secretion.

This study identifies CTCF and cohesin as essential for chromatin-nuclear speckle association, showing their role in gene inducibility and relevance to disease.

This study shows HIRA and PML regulate SASP through interactions with p62/SQSTM1 and the cGAS-STING pathway in senescent cells.

The paper investigates how enhancer interactomes reconfigure during senescence and aging, identifying hyper-connected enhancer communities linked to gene expression and potential therapeutic targets.

The paper shows the blood-brain barrier regulates social behavior in ants by controlling hormone levels via a key enzyme, with implications for conserved mechanisms across species.

This study shows that inhibiting Acss2 reduces fear memory formation and anxiety in mice and rats by decreasing histone acetylation and gene expression in the hippocampus.

This study identifies spurious intragenic transcription as a conserved hallmark of mammalian cellular senescence and tissue aging, impacting cellular health and transcriptional networks.

The paper identifies a heat shock factor, hsalHSF2, that contributes to extended lifespan in reproductive ants and shows its transferable role in enhancing survival in fruit flies.

The paper uses single-cell RNA-sequencing to show that caste transition in ants leads to glia remodeling associated with extended lifespan.

The paper shows that inducing DNA breaks accelerates aging-related chromatin changes and loss of cell identity in mammals.

This study identifies impaired death receptor signaling as a driver of resistance to CAR T cell therapy in B-cell leukemia by showing its role in tumor survival and T cell dysfunction.

The paper compares genotoxic and non-genotoxic p53 activation in human fibroblasts, showing similar genome-wide binding and chromatin changes but distinct inflammatory gene expression patterns.

This study uses CRISPR to knock out the Orco gene in ants, showing its role in olfaction, social behavior, and neural plasticity.