Tali Kiperman

Circadian Clock Coordination of the Notch-to-Wnt Signaling Switch Promotes Regenerative Myogenesis

This study identifies the circadian clock's role in coordinating the Notch-to-Wnt signaling switch to enhance regenerative myogenesis in muscle stem cells.

Circadian Clock Control of Muscle Stem Cells Through Temporal Coordination of Notch and Wnt Signaling

This study shows the circadian clock coordinates Notch and Wnt signaling in muscle stem cells to regulate regeneration, with functional effects in dystrophic muscle and human myoblasts.

Quercetin and Fisetin activate circadian clock via RORα and inhibit adipocyte growth

This study identifies Quercetin and Fisetin as clock-activating compounds that inhibit adipocyte growth and lipid metabolism via RORα activation.

Novel circadian clock activators display anti-obesity efficacy via suppression of adipocyte development and hypertrophy

This paper identifies novel clock activators, chlorhexidine and CM002, that suppress adipocyte development and hypertrophy, leading to anti-obesity effects in mice.

STX4 is indispensable for mitochondrial homeostasis in skeletal muscle

This study shows STX4 is essential for mitochondrial homeostasis in skeletal muscle by regulating mitochondrial biogenesis and mitophagy.

Clock Modulation by Naringenin via RORα Suppresses Lipogenesis and Promotes Adipose Tissue Browning

This study shows naringenin modulates the circadian clock via RORα to suppress lipogenesis and promote adipose browning, improving metabolic health.

Targeted Screening and Identification of Chlorhexidine as a Pro-myogenic Circadian Clock Activator

This paper identifies chlorhexidine as a circadian clock activator that promotes myogenesis through enhanced CLOCK/Bmal1 transcriptional activity.