David Horne

This study develops CYP8B1-specific inhibitors that alter bile acid composition, remodel gut microbiota, and improve metabolic disease in a mouse model.

This study shows the circadian clock coordinates Notch and Wnt signaling in muscle stem cells to regulate regeneration, with functional effects in dystrophic muscle and human myoblasts.

This paper identifies novel clock activators, chlorhexidine and CM002, that suppress adipocyte development and hypertrophy, leading to anti-obesity effects in mice.

This study shows that inhibiting H3K9me3 with ETP69 reduces AD pathology and improves cognition by modulating neuroinflammation and inducing Vgf.

This study identifies chlorhexidine and its derivative CM002 as clock activators with anti-adipogenic properties, showing they inhibit adipogenesis via Wnt pathway activation.

This paper identifies chlorhexidine as a circadian clock activator that promotes myogenesis through enhanced CLOCK/Bmal1 transcriptional activity.