Cancer BiologybioRxivPreprint
Evolutionary Action Score of TP53 Mutations: Integrated Clinico-pathologic And Protein Structural Analysis in Myelodysplastic Syndromes
Rashmi Kanagal-Shamanna, Guillermo Montalban-Bravo, Panagiotis Katsonis…·Guillermo Garcia-Manero
The paper quantifies the impact of TP53 mutations in myelodysplastic syndromes using an evolutionary action score and correlates it with clinical and genomic features, finding that low-EAp53 mutations are associated with better survival.
DOI 10.1101/2020.07.08.194365