Cancer BiologybioRxivPreprint
BET BD2 inhibition facilitates SPOP-mediated degradation of chromatin-associated BRD4/BRD4-NUT, a therapeutic vulnerability in NUT carcinoma
Kathleen Bates, Hoang Nguyen, Kyle P. Eagen…·Christopher Alexander French
The paper shows that selective inhibition of BRD4-BD2 promotes SPOP-mediated degradation of BRD4/BRD4-NUT in NUT carcinoma, leading to better therapeutic outcomes than pan-BET inhibition.
DOI 10.64898/2026.08.14.744905