A Non-canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver
Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene-Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany N. Hannafon, Courtney W. Houchen, , Sathyaseelan S. Deepa
This study shows that MLKL in hepatocytes promotes liver aging by inducing senescence and mitochondrial dysfunction without causing necroptosis.
Aging Cell · Jul 1, 2026Peer-reviewedCell Biology