PDE4 inhibitor Rolipram represses hedgehog signaling via ubiquitin-mediated proteolysis of GLI transcription factors to regress breast cancer
A. Bagchi, A. Bhattacharya, U. Chatterji, A. BISWAS
Rolipram inhibits hedgehog signaling by promoting ubiquitination and degradation of GLI2FL and GLI3FL, reducing GLI1 levels and tumor growth in breast cancer models.
bioRxiv · Mar 3, 2024Cancer Biology