P. Mukherjee

Amino Acid and Glucose Fermentation Maintain ATP Content in Mouse and Human Malignant Glioma Cells

This study shows that malignant glioma cells rely on amino acid and glucose fermentation for ATP production, not oxidative phosphorylation, and that glutamine is essential for maintaining ATP content and viability.

Emergent emm4 group A Streptococcus evidences a survival strategy during interaction with immune effector cells

This study identifies a survival strategy in emm4 group A Streptococcus strains through downregulation of SLO and upregulation of msrAB, enabling better macrophage survival without increased virulence.

LiaR-dependent gene expression contributes to antimicrobial responses in group A Streptococcus

This study identifies the LiaFSR regulon in Group A Streptococcus and shows how phosphorylated LiaR regulates virulence and AMP resistance via SpxA2 and other genes.

Extracellular matrix signals promotes actin-dependent mitochondrial elongation and activity

This study shows that ECM signals induce mitochondrial elongation and activity through actin polymerization and integrin signaling in mammospheres.

Galectin-3-binding protein inhibits extracellular heparan 6-O-endosulfatse Sulf-2

This study identifies LG3BP as a binding partner of Sulf-2 in HNSCC and shows that LG3BP inhibits Sulf-2 activity, reducing HNSCC cell invasion.

Heparan-6-O-endosulfatase 2 promotes invasiveness of head and neck squamous carcinoma cell lines in co-cultures with cancer associated fibroblasts

This study shows that Sulf-2 promotes HNSCC cell invasion in co-cultures with CAFs, and a marine glycosaminoglycan inhibits this effect.

Label-free visualization and quantification of the drug-type-dependent response of tumor spheroids by dynamic optical coherence tomography

This study uses dynamic optical coherence tomography to quantify tumor spheroid responses to three anti-cancer drugs, showing drug-specific structural and signal changes over time.

Effect of Water Fluoridation on VM-M3 Tumor Metastasis

This study investigates the effect of water fluoridation on tumor metastasis using VM-M3/Fluc tumor cells in mice, finding no significant impact on metastasis or survival.

PAS domain of flagellar histidine kinase FlrB exhibits novel architecture, and binds Heme as sensory signal in unconventional fashion

The paper reports the crystal structure of FlrB's PAS domain and identifies heme as a sensory ligand, showing synergistic binding with ATP to regulate flagellar gene transcription in Vibrio cholerae.

Overexpression of MUC1 influences the anti-proliferative effect of STAT3-inhibitor Napabucasin in epithelial cancers.

This study shows that overexpressed MUC1 enhances the anti-proliferative effect of the STAT3 inhibitor Napabucasin in epithelial cancers.

Ketogenic diet as a metabolic vehicle for enhancing the therapeutic efficacy of mebendazole and devimistat in preclinical high-grade gliomas grown in juvenile mice

This study shows that combining a ketogenic diet with mebendazole or devimistat improves therapeutic outcomes in preclinical high-grade glioma models in juvenile mice.

Renal tubular function and morphology revealed in kidney without labeling using three-dimensional dynamic optical coherence tomography

This study uses 3D dynamic OCT to image renal tubule function and morphology in normal and obstructed mouse kidneys without labeling.

An Arm-to-Disarm Strategy to Overcome Phenotypic AMR in Mycobacterium tuberculosis

This paper develops a prodrug strategy to overcome phenotypic AMR in Mtb by enhancing drug permeability and targeting hypoxic persisters.

A small-molecule myosin inhibitor as a targeted multi-stage antimalarial

This paper develops a small-molecule myosin inhibitor, KNX-115, effective against multiple stages of Plasmodium infection with high selectivity and potency.

Activation of ERK by altered RNA splicing in cancer

The paper shows that SMNDC1, an upregulated splicing factor in cancer, promotes tumor growth by enhancing ERK1 kinase activity through altered RNA splicing of exon 4.

Extent of Molecular Chaperone Association Might Determine Fates of Membraneless Organelles during Aging in C. elegans

The paper investigates how molecular chaperone association affects membraneless organelles (MLOs) in C. elegans during aging, finding that long-lived mutants exhibit increased protein aggregation and potential protective states.

Early loss of endogenous NAD+ following rotenone treatment leads to Sarm1 induction that is ameliorated by PARP inhibition

This study shows that rotenone treatment causes early NAD+ loss, leading to Sarm1 activation, which is prevented by PARP inhibition in both cell cultures and Drosophila.

Elucidating the correlation between the number of TTTTGAT heptamer repeats and cholera toxin promoter activity in Vibrio cholerae O1 pandemic strains

Repression of MUC1 promotes expansion and suppressive function of myeloid-derived suppressor cells in pancreatic ductal adenocarcinoma and breast cancer murine models.

This study shows that MUC1 repression in MDSCs enhances their proliferation and suppressive function in pancreatic and breast cancer models, leading to increased tumor growth and immune suppression.

Tumor -Associated MUC1 Regulates TGF-β Signaling and Function in Pancreatic Ductal Adenocarcinoma

This study shows that high tMUC1 expression in PDA correlates with altered TGF-β signaling, promoting tumor growth and resistance to TGF-β therapy.

Overcoming Immunological Resistance Enhances the Efficacy of a Novel anti-tMUC1 CAR T Cell Treatment Against Pancreatic Ductal Adenocarcinoma

This study develops a novel tMUC1-targeting CAR T cell therapy for pancreatic ductal adenocarcinoma and shows that combining it with inhibitors of IDO1, COX1/2, and Gal-9 enhances its efficacy against resistant tumors.

A Combined Numerical and Experimental Investigation of Localized Electroporation-based Transfection and Sampling

This study combines numerical modeling and experiments to investigate localized electroporation for transfection and sampling, finding that membrane tension enhances molecular transport efficiency.