Gasdermin D is the only Gasdermin that provides non-redundant protection against acute Salmonella gut infection
S. A. Fattinger, L. Maurer, P. Geiser, U. Enz, S. Ganguillet, E. Gul, S. Kroon, B. Demarco, M. Furter, M. Barthel, P. Pelczar, F. Shao, P. Broz, M. E. Sellin, W.-D. Hardt
This study identifies Gasdermin D as the only Gasdermin providing non-redundant protection against acute Salmonella Typhimurium gut infection by restricting bacterial loads, controlling inflammation, and preventing epithelial disruption.
bioRxiv · Nov 24, 2022Immunology