Author

U. Hetzel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 5 Organism:non-human primate· 4 Assay:metagenomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Organism:human· 1

Frequent Co-Authors

A. Kipar· 8 shared J. Hepojoki· 8 shared L. Szirovicza· 6 shared T. Smura· 4 shared O. Vapalahti· 3 shared F. Baggio· 2 shared A. Alfaro-Alarcon· 1 shared A. Lintala· 1 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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8 shared papersMicrobiology

A. Kipar

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Unraveling human, rodent and snake Kolmioviridae replication to anticipate cross-species transmission

K. Majzoub, P. Khalfi, Z. Denis, G. Merolla, C. Chavey, J. Ursic-Bedoya, L. Soppa, L. Szirovicza, U. Hetzel, J. Dufourt, C. Leyrat, N. Goldmann, K. Goto, E. Verrier, T. F. Baumert, , J. Hepojoki

This study compares the replication of three Kolmioviridae viruses in vitro and in vivo, revealing differences in host range and replication efficiency.

bioRxiv · May 17, 2023 · PreprintMicrobiology

Reptarenavirus Co- and Superinfection in Cell Culture Sheds Light on the S and L Segment Accumulation in Captive Snakes

A. Lintala, L. Szirovicza, A. Kipar, U. Hetzel, J. Hepojoki

This study investigates reptarenavirus co- and superinfection in cell cultures, finding no competition between closely related viruses but reduced replication of closely related segments in persistently infected cells.

bioRxiv · Oct 17, 2022 · PreprintMicrobiology

Boid Inclusion Body Disease (BIBD) Is Also a Disease of Wild Boa Constrictors

A. Alfaro-Alarcon, U. Hetzel, T. Smura, F. Baggio, J. A. Morales, A. Kipar, J. Hepojoki

This paper identifies reptarenavirus infection and Boid Inclusion Body Disease (BIBD) in wild and captive boa constrictors in Costa Rica, showing the disease occurs in wild populations and suggesting boas may contribute to natural virus circulation.

bioRxiv · Apr 25, 2022Microbiology

Arenavirus nucleoprotein localizes to mitochondria

F. Baggio, U. Hetzel, L. Nufer, A. Kipar, J. M. Hepojoki

This study shows that arenavirus nucleoprotein localizes to mitochondria, affecting their morphology and potentially modulating immune responses.

bioRxiv · Nov 6, 2020 · PreprintMicrobiology

Experimental Reptarenavirus Infection of Boa constrictor and Python regius

U. Hetzel, Y. Korzyukov, S. Keller, L. Szirovicza, T. Pesch, O. Vapalahti, A. Kipar, J. Hepojoki

This study experimentally infects pythons and boas with reptarenavirus via different routes, finding infection without inclusion bodies and suggesting other factors contribute to BIBD pathogenesis.

bioRxiv · Oct 5, 2020Microbiology

Identification of Reptarenaviruses, Hartmaniviruses and a Novel Chuvirus in Captive Brazilian Native Boa Constrictors with Boid Inclusion Body Disease

F. F. Argenta, J. Hepojoki, T. Smura, L. Szirovicza, M. E. Hammerschmitt, D. Driemeier, A. Kipar, U. Hetzel

The paper identifies novel reptarenaviruses, hartmaniviruses, and a chuvirus in Brazilian captive boas with Boid Inclusion Body Disease using metatranscriptomic analysis.

Journal of Virology · May 18, 2020Peer-reviewedMicrobiology

Python nidoviruses, more than respiratory pathogens

E. Dervas, J. Hepojoki, T. Smura, B. Prähauser, K. Windbichler, S. Blumich, A. Ramis, U. Hetzel, A. Kipar

This study investigates python nidoviruses, finding they infect multiple tissues beyond the respiratory tract and spread systemically via monocytes, challenging previous understanding of their tropism and disease patterns.

bioRxiv · Apr 10, 2020 · PreprintPathology

Snake deltavirus utilizes envelope proteins of different viruses to generate infectious particles

L. Szirovicza, U. Hetzel, A. Kipar, L. Martinez-Sobrido, O. Vapalahti, J. Hepojoki

This study shows snake deltavirus can use various helper viruses or viral glycoproteins to generate infectious particles, expanding the known range of helper viruses beyond hepatitis B virus.

bioRxiv · Jul 11, 2019Microbiology

Identification of a novel deltavirus in Boa constrictor

U. Hetzel, L. Szirovicza, T. Smura, B. Prahauser, O. Vapalahti, A. Kipar, J. Hepojoki

The paper identifies a novel deltavirus, sHDV, in Boa constrictor, showing it replicates independently of HBV and spreads via vertical and horizontal transmission.

bioRxiv · Sep 29, 2018Microbiology