O. Vapalahti

This study shows that the N-terminal fragment of α-dystroglycan blocks SARS-CoV-2 and other enveloped viruses in cell culture and animal models.

This study investigates an equine dermatitis outbreak in Finland, identifies EqPPV as the causative agent, and highlights zoonotic transmission risks and risk factors.

This study shows that combining PIKfyve and TMPRSS2 inhibitors intranasally protects mice from SARS-CoV-2 lung infection and reduces cell death.

This study identifies alternative cell entry mechanisms for SARS-CoV-2 and other viruses, showing some rely on dynamin while others use actin-dependent pathways.

The paper reports a sequencing protocol and 121 kb poxvirus sequence from a horse with dermatitis, identifying a novel parapoxvirus associated with a recent epidemic and suggesting zoonotic potential.

This study shows that inhibiting host N-myristoylation reduces SARS-CoV-2 infectivity by impairing viral envelope protein maturation and causing Golgi-bypassing egress.

This study engineers nanobodies to neutralize SARS-CoV-2 variants and develop a detection assay, showing high potency against some variants but limitations against others.

This study describes KZR-8445, a cyclic depsipeptide that selectively inhibits Sec61-mediated protein biogenesis by mimicking signal peptides, showing efficacy in a rheumatoid arthritis model.

This study shows SARS-CoV-2 requires acidic pH for membrane fusion and genome release, even after proteolytic cleavage by furin or TMPRSS2.

This study infects mink with SARS-CoV-2 Omicron variant and shows they remain virus positive, develop symptoms, and transmit the virus.

This paper describes a novel intranasal inhibitor, TriSb92, that effectively neutralizes SARS-CoV-2 and recent Omicron subvariants, offering protection against infection in mice.

This paper identifies 59 high confidence virus-host protein interactions between tick-borne encephalitis virus and neuroblastoma cells using chemical cross-linking and mass spectrometry.

This study finds that combining apilimod and camostat mesylate or nafamostat mesylate significantly enhances inhibition of SARS-CoV-2 infection in vitro.

The paper identifies two compounds that inhibit SARS-CoV-2 infection and syncytia formation through computational prioritization and in vitro testing.

This study tests antidepressants and antipsychotics against SARS-CoV-2 pseudoviruses and finds fluoxetine inhibits infection, including against variants with spike mutations.

This study shows that neuropilin-1 enhances SARS-CoV-2 infectivity and facilitates viral entry into the central nervous system via the olfactory pathway.

This study experimentally infects pythons and boas with reptarenavirus via different routes, finding infection without inclusion bodies and suggesting other factors contribute to BIBD pathogenesis.

This study investigates how a monoclonal antibody neutralizes hantaviruses by targeting the glycoprotein lattice, revealing structural insights into antibody binding and its impact on viral entry.

This study develops an experimental system to investigate immunoregulatory responses in bank voles infected with PUUV, revealing that virus-induced interleukin-10 promotes persistent infections by suppressing immune responses.

This study shows snake deltavirus can use various helper viruses or viral glycoproteins to generate infectious particles, expanding the known range of helper viruses beyond hepatitis B virus.

The paper identifies a novel deltavirus, sHDV, in Boa constrictor, showing it replicates independently of HBV and spreads via vertical and horizontal transmission.

The paper identifies neutralizing epitopes on hantavirus glycoproteins using pseudotyped VSV particles and site-directed mutagenesis, showing specific amino acid residues critical for antibody neutralization.