A missense KCNQ1 Mutation Impairs Insulin Secretion in Neonatal Diabetes
Z. Zhou, M. Gong, A. Pande, U. Lisewski, T. Röpke, B. Purfürst, L. Liang, S. Jia, S. Frühler, A. Margineanu, C. Zeng, H. Zhu, P. Kühnen, S. Khodaverdi, W. Krill, , Z. Izsvak
This study identifies a KCNQ1 mutation causing neonatal diabetes by impairing β-cell function and survival through electrophysiological and transcriptomic analyses.
bioRxiv · Aug 24, 2021 · PreprintCell Biology