H. Zhu

ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.

Development of a LRRC15-Targeted Radio-Immunotheranostic Approach to Deplete Pro-tumorigenic Mechanisms and Immunotherapy Resistance

This paper develops a radio-theranostic approach targeting LRRC15 to image and treat cancer, showing tumor reduction and reversal of immunotherapy resistance.

Liver cancer initiation is dependent on metabolic zonation but decoupled from premalignant clonal expansion

This study shows that liver cancer initiation depends on metabolic zonation but is not linked to premalignant clonal expansion.

CCT3 drives Sorafenib resistance by inhibiting TFRC-mediated iron uptake in HCC

This study identifies CCT3 as a driver of Sorafenib resistance in HCC by inhibiting TFRC-mediated iron uptake, leading to ferroptosis resistance.

Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

This study identifies breast cancer subtypes and their lineage origins by analyzing chromatin accessibility and transcriptional dynamics using multi-omic techniques.

A peptide-centric local stability assay to unveil protein targets of diverse ligands

This paper introduces PELSA, a peptide-centric local stability assay that identifies ligand-binding regions across the proteome with high sensitivity and without ligand modification.

PD-L1 Restrains the PD-1hiNrp1loTGFb+ Treg to block IL6+ Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

This study shows PD-L1 suppresses inflammation-driven colorectal cancer by regulating Tregs, neutrophils, and gut microbiota through the PD-L1/L. murinus/PD-1hiNrp1loTGFβ+ Treg/IL6+ neutrophils pathway.

Continuous Tracking using Deep Learning-based Decoding for Non-invasive Brain-Computer Interface

This paper develops deep learning-based decoders for continuous brain-computer interface (BCI) control and shows they improve performance over time and outperform traditional methods in complex tasks.

Computational design of N-linked glycans for high throughput epitope profiling

The paper develops a computational method using N-linked glycans to rapidly map epitopes, validated through ELISA, yeast display, and X-ray crystallography using human coagulation factor IXa.

Structural basis for the allosteric regulation and dynamic assembly of DNMT3B

This study determines the cryo-EM structure of DNMT3B under various oligomerization states, revealing how its domains interact to regulate its assembly and function.

Polymerization force-regulated actin filament-Arp23 complex interaction dominates self-adaptive cell migrations

This study develops a multiscale model showing that polymerization force-regulated actin-Arp2/3 interactions enable cells to adaptively migrate through heterogeneous ECMs via opposing feedback mechanisms.

Butyrate Protects against SARS-CoV-2-induced Tissue Damage in Golden Hamsters.

This study shows butyrate protects against SARS-CoV-2-induced tissue damage in golden hamsters by enhancing antiviral immunity and reducing oxidative stress.

Multi-frame biomechanical and relaxometry analysis during in vivo loading of the human knee by spiral dualMRI and compressed sensing

This study uses spiral DENSE MRI and compressed sensing to analyze knee cartilage biomechanics during in vivo loading, showing strain patterns and reduced scan times.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

This study shows that chromosomal instability in cancer cells can enhance macrophage-mediated immune responses and induce a broad anti-tumor IgG response, improving survival when combined with CD47-SIRP checkpoint disruption.

Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC

The paper describes piperidine-based CD4-mimetic compounds that expose HIV-1 Env epitopes, increasing sensitivity to ADCC by targeting Asp368.

Positive selection of somatically mutated clones identifies adaptive pathways in metabolic liver disease

The paper identifies adaptive pathways in metabolic liver disease by selecting somatically mutated clones in mice and humans, finding mutations that ameliorate lipotoxicity and promote clonal expansion.

LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration

This study shows that LIFR in hepatocytes regulates neutrophil recruitment and activity to promote liver regeneration through CXCL1-CXCR2 and cholesterol-HGF pathways.

Cancer mutations rewire the RNA methylation specificity of METTL3-METTL14

The paper shows that a cancer mutation in METTL14 changes RNA methylation specificity, promoting oncogenesis by altering gene expression without increasing global m6A levels.

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

This study identifies cross-reactive intrahepatic antibodies in severe alcoholic hepatitis that target both bacterial antigens and human proteins, suggesting a role in disease pathogenesis.

Antibody-mediated cell entry of SARS-CoV-2

This study shows that certain monoclonal antibodies can replace ACE2 to mediate SARS-CoV-2 entry into cells, indicating that ACE2 is not essential for viral infection.

High-throughput screening of functional neo-antigens and their specific TCRs via the Jurkat reporter system combine with droplet microfluidics

The paper develops a high-throughput platform for screening functional neo-antigens and their specific TCRs using droplet microfluidics and DNA barcoding.

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

The paper reports a cryo-EM structure of the SARS-CoV-2 postfusion spike in a membrane, revealing structural details of membrane-interacting segments.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Germline determinants of the prostate tumor genome

The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.

MSP1 encodes an essential RNA-binding PPR factor required for nad1 maturation and complex I biogenesis in Arabidopsis mitochondria

This study identifies MSP1 as an essential PPR protein required for nad1 RNA processing and complex I biogenesis in Arabidopsis mitochondria, leading to seed abortion in its loss-of-function mutants.

Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoids

This study shows that engineered vasculature enhances the function of stem cell-derived islet organoids by improving calcium influx and insulin secretion in beta-cells.

Multi-dimensional protein solubility optimization with an ultra-high-throughput microfluidic platform

This paper introduces a high-throughput microfluidic platform for protein solubility screening, enabling rapid and efficient optimization of formulation additives and mutations.

Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation

This study uses single-cell RNA-seq to analyze immune cells in ME/CFS patients at baseline and after exercise, identifying dysregulated monocytes and platelet transcriptomes.

Intranasal delivery of NS1-deleted influenza virus vectored COVID-19 vaccine restrains the SARS-CoV-2 inflammatory response

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.