C. Zeng

A broad cathepsin inhibitor blocks crystal-stimulated inflammasome-dependent and -independent inflammation, and gout arthritis

This study shows that broad-spectrum cathepsin inhibitors block crystal-induced inflammation and gout arthritis by inhibiting both inflammasome-dependent and -independent pathways that generate IL-1β.

Metabolic control of adaptive β-cell proliferation by the protein deacetylase SIRT2

This study identifies SIRT2 as a regulator of β-cell proliferation, showing its role in controlling β-cell expansion during hyperglycemia while preserving feedback mechanisms.

SeMOE allows for quantitative glycan perception and exhibits anti-cancer potentiality

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

Semiconductor augumented valuable chemical photosynthesis from Rhodospirillum rubrum and mechanism study

This paper constructs a Rhodospirillum rubrum-CdS biohybrid system and investigates its enhanced photosynthetic activity and electron transfer mechanisms.

Determinants and Mechanisms of the Low Fusogenicity and Endosomal Entry of Omicron Subvariants

This study identifies mutations in the Omicron subvariant spike protein that reduce fusogenicity and increase endosomal entry, revealing mechanisms behind their immune evasion and pathogenesis.

Protection from Omicron and other VOCs by Bivalent S-Trimer COVID-19 Vaccine

This study develops a bivalent S-Trimer vaccine combining ancestral and Omicron S-proteins, showing enhanced neutralizing antibody responses against VOCs.

Prime-pull immunization of mice with a BcfA-adjuvanted vaccine elicits mucosal immunity and prevents SARS CoV-2 infection and pathology

Near-atomic Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

Loss of Neutralizing Antibody Response to mRNA Vaccination against SARS-CoV-2 Variants: Differing Kinetics and Strong Boosting by Breakthrough Infection

This study examines the decline of neutralizing antibody responses to SARS-CoV-2 variants after mRNA vaccination and shows that breakthrough infection boosts antibody levels.

Cryo-EM structure of the Inner Ring from Xenopus laevis Nuclear Pore Complex

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.

A missense KCNQ1 Mutation Impairs Insulin Secretion in Neonatal Diabetes

This study identifies a KCNQ1 mutation causing neonatal diabetes by impairing β-cell function and survival through electrophysiological and transcriptomic analyses.

NSUN2-mediated m5C methylation of IRF3 mRNA negatively regulates type I interferon responses

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

SARS-CoV-2 Spreads through Cell-to-Cell Transmission

This study shows SARS-CoV-2 spreads through cell-to-cell contact via spike glycoprotein, which is more efficient than SARS-CoV and resistant to neutralizing antibodies.

Differential gene expression by RNA-Seq in Sigma-2 Receptor/TMEM97 knockout cells reveals its role in complement activation and SARS-CoV-2 viral uptake

This study uses RNA-Seq to identify differentially expressed genes in sigma-2R/TMEM97 knockout cells, revealing its role in complement activation and SARS-CoV-2 viral uptake.

Leveraging mRNAs sequences to express SARS-CoV-2 antigens in vivo

This study identifies an optimized mRNA UTR combination (NASAR) that significantly enhances SARS-CoV-2 antigen expression in vitro and in vivo.

Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex

The paper reports the cryo-ET structure of the luminal ring of the Xenopus laevis nuclear pore complex and identifies key structural features confirmed by cryo-EM.

Structure of the Cytoplasmic Ring of the Xenopus laevis Nuclear Pore Complex

The paper presents a high-resolution cryo-EM structure of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing new structural features and interactions.

Diagnostic value of galactomannan in bronchoalveolar lavage fluid for chronic respiratory disease with pulmonary aspergillosis

This study evaluates the diagnostic value of bronchoalveolar lavage fluid galactomannan (BALF GM) for pulmonary aspergillosis in chronic respiratory disease, finding an optimal cut-off value of 0.485 with high sensitivity and specificity.

Novel 5-Hydroxymethylcytosine Markers for Pancreatic Cancer

The paper investigates 5-hydroxymethylcytosine (5hmC) as a potential biomarker for pancreatic cancer, showing distinct distributions in tumor and adjacent tissues.