L. Liang

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

An open-source MRI compatible frame for multimodal presurgical mapping in macaque and capuchin monkeys

The paper introduces an open-source, 3D-printable MRI-compatible stereotaxic frame for nonhuman primates, enabling accurate multimodal presurgical mapping and deep-brain interventions.

Evaluation of Deep Neural Network Models for Instance Segmentation of Lumbar Spine MRI

This paper evaluates 15 DNN models for instance segmentation of lumbar spine MRI using a new synthetic dataset and two metrics.

Mechanical confinement induces ferroptosis through mitochondrial dysfunction

This study shows that mechanical confinement triggers ferroptosis via mitochondrial dysfunction by inducing Drp1-dependent fragmentation and cPLA2 translocation.

RFX6 at locus 6q22 confers metastasis and drug resistance in prostate cancer

This study identifies RFX6 at locus 6q22 as a driver of prostate cancer metastasis and drug resistance through epigenetic and genetic mechanisms.

Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168

This study determines the cryo-EM structures of RNF168/UbcH5c-Ub/nucleosome complexes to elucidate the mechanism of H2A K13/K15 site-specific ubiquitination.

Population genetic analyses of longitudinal vaginal microbiome reveal racioethnic evolutionary dynamics and prevailing positive selection of Lactobacillus adhesins

This study analyzes longitudinal vaginal microbiome data from diverse ethnic groups, revealing ethnic signatures in microbial diversity, community states, and evolutionary dynamics, with Lactobacillus adhesins showing positive selection.

Biomechanical stress analysis of Type-A aortic dissection at pre-dissection, post-dissection, and post-repair states

This study uses finite element analysis on CT images to analyze biomechanical stress changes in aortic dissection across pre-dissection, post-dissection, and post-repair states, revealing increased wall stress and stress concentration regions.

NEDD4-binding protein 1 suppresses HBV replication by degrading HBV RNAs

This paper identifies N4BP1 as a host factor that suppresses HBV replication by degrading HBV RNAs, with its KH-like and RNase domains required for this effect.

Nifuroxazide Suppresses PD-L1 Expression and Enhances the Efficacy of Radiotherapy in Hepatocellular Carcinoma

This study shows nifuroxazide enhances radiotherapy in HCC by reducing PD-L1 expression and improving tumor response.

Structural Visualization of HECT-type E3 ligase Ufd4 Accepting and Transferring Ubiquitin to Form K29/K48-branched Polyubiquitination

This study determines the structural mechanism of HECT-type E3 ligase Ufd4 in catalyzing K29/K48-branched polyubiquitination by capturing structural snapshots of Ub transfer cascades.

Identification of a novel MCR-1 variant displaying low level of co-resistance to β-lactam antibiotics that uncovers a potential novel antimicrobial peptide

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

Synergistic Integration of Deep Neural Networks and Finite Element Method with Applications for Biomechanical Analysis of Human Aorta

This paper integrates deep neural networks with finite element methods to improve biomechanical analysis of the human aorta, reducing errors and computational time.

PyTorch-FEA: Autograd-enabled Finite Element Analysis Methods with Applications for Biomechanical Analysis of Human Aorta

PyTorch-FEA improves computational efficiency and accuracy in biomechanical analysis of human aorta using autograd and deep learning.

Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysis

This study characterizes the tumor microenvironment in colorectal cancer using multi-omics and spatial analysis, identifying four subtypes with distinct features and therapeutic responses.

Taxonomic and carbon metabolic diversification of Bathyarchaeia during its co-evolution history with the early Earth surface environment

This study investigates the evolutionary history and metabolic diversity of Bathyarchaeia, linking their diversification to geological events and environmental changes.

Deleterious Mechanical Deformation Selects Mechanoresilient Cancer Cells with Enhanced Proliferation and Chemoresistance

The paper shows that mechanical deformation selects for cancer cells with enhanced proliferation and chemoresistance, linking physical microenvironmental barriers to metastatic malignancy.

The fitness landscape of the mobilized colistin resistance gene mcr-1

The paper generates and analyzes an mcr-1 mutant library to assess the impact of mutations on colistin resistance, finding that most mutations in the catalytic domain reduce resistance.

Global Mutational Sweep of SARS-CoV-2: from Chaos to Order

The paper analyzes SARS-CoV-2 genome sequences to show mutation sweeps driven by emerging variants, which may prolong the pandemic and challenge control efforts.

DNA Self-Assembled Plasmonic Nanodiamonds for Biological Sensing

This study develops plasmon-enhanced nanodiamonds (PEN) for biological imaging by using DNA self-assembly to improve brightness and temporal resolution of NV centers.

Reassortment Network of Influenza A Virus

This study analyzes the reassortment network of Influenza A Virus using genome-wide data to identify reassortment events and their evolutionary implications.

A missense KCNQ1 Mutation Impairs Insulin Secretion in Neonatal Diabetes

This study identifies a KCNQ1 mutation causing neonatal diabetes by impairing β-cell function and survival through electrophysiological and transcriptomic analyses.

Cytolytic memory CD4+ T cell clonotypes are expanded during Plasmodium falciparum infection

The paper identifies clonally expanded cytolytic memory CD4+ T cells in Plasmodium falciparum malaria patients and links their reduced chemotactic and inhibitory receptor expression to clinical immunity.

Structural Insights Into the Initiation and Elongation of Ubiquitination by Ubr1

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

A Probabilistic and Anisotropic Failure Metric for Ascending Thoracic Aortic Aneurysm Risk Stratification

This paper introduces a probabilistic and anisotropic failure metric to improve risk stratification for ascending thoracic aortic aneurysm by incorporating patient-specific biomechanical data and uncertainty in wall strength.

Gluconeogenic Enzyme PCK1 Deficiency Is Critical for CHK2 O-GlcNAcylation and Hepatocellular Carcinoma Growth upon Glucose Deprivation

This study shows that PCK1 deficiency increases O-GlcNAcylation and promotes HCC growth under glucose deprivation by enhancing CHK2 activity.

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

A Live Attenuated Vaccine Model Confers Cross-Protective Immunity Against Different Species of Leptospira spp.

The paper evaluates a live attenuated Leptospira mutant as a vaccine candidate, showing it induces cross-protective immunity against multiple Leptospira species.

Elucidating Direct Kinase Targets of Compound Danshen Dropping Pills Employing Archived Data and Prediction Models

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

O-GlcNAcylation of SAMHD1 Indicating a Link between Metabolic Reprogramming and Anti-HBV Immunity

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.