Bone morphogenetic protein 4 gene therapy in mice inhibits myeloma tumor growth, but has a negative impact on bone
M. Westhrin, T. Holien, M. Zahoor, S. H. Moen, G. Buene, B. Stordal, H. Hella, H. Yuan, J. D. de Bruijn, A. Martens, R. W. Groen, F. Bosch, U. Smith, A. M. Sponaas, A. Sundan, T. Standal
This study shows that BMP4 gene therapy reduces myeloma tumor growth in mice but also decreases trabecular bone volume.
bioRxiv · Mar 13, 2019Cancer Biology