Author

T. Holien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

G. Buene· 2 shared H. Hella· 2 shared A. Bugai· 1 shared A. F. Arutyunyan· 1 shared A. Ianevski· 1 shared A. L. Zhuze· 1 shared A. M. Sponaas· 1 shared A. Martens· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

G. Buene

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Chemical, physical and biological triggers of Bcl-xL-mediated apoptosis

A. Ianevski, E. Kulesskiy, K. Krpina, G. Lou, Y. Aman, A. Bugai, K. Aasumets, Y. Akimov, D. Bulanova, K. Gildemann, A. F. Arutyunyan, O. Y. Susova, A. L. Zhuze, P. Ji, W. Wang, , D. E. Kainov

This study shows that Bcl-xL-specific inhibitors, when combined with DNA-damaging agents or physical insults, trigger apoptosis in various cell types and C. elegans by releasing Bad and Bax from Bcl-xL.

bioRxiv · Jan 13, 2020Cancer Biology

Bone morphogenetic protein 4 gene therapy in mice inhibits myeloma tumor growth, but has a negative impact on bone

M. Westhrin, T. Holien, M. Zahoor, S. H. Moen, G. Buene, B. Stordal, H. Hella, H. Yuan, J. D. de Bruijn, A. Martens, R. W. Groen, F. Bosch, U. Smith, A. M. Sponaas, A. Sundan, T. Standal

This study shows that BMP4 gene therapy reduces myeloma tumor growth in mice but also decreases trabecular bone volume.

bioRxiv · Mar 13, 2019Cancer Biology

BMPR2 inhibits activin- and BMP-signaling via wild type ALK2

O. E. Olsen, M. Sankar, S. Elsaadi, H. Hella, G. Buene, S. R. Darvekar, K. Misund, T. Katagiri, T. Holien

The paper shows that knocking down BMPR2 enhances SMAD1/5/8 activation by activin A, activin B, and certain BMPs through wild type ALK2 in multiple myeloma cells.

bioRxiv · Nov 22, 2017Cell Biology