H. Yuan

This study examines the gut virome in MS patients, finding reduced diversity and specific taxonomic changes compared to healthy controls.

The paper analyzes paternal genomic data from the YanHuang cohort to propose a Weakly-Differentiated Multi-source Admixture model for the formation of Han Chinese ancestral lineages.

This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.

This study develops a high-throughput plasma proteome analysis workflow using UV-assisted digestion, 5-plex labeling, and MS-based high abundance protein removal to improve quantification of low-abundance proteins.

This paper develops an alternating polarity strategy to cultivate electro-methanogenic microbial communities, resulting in higher biogas production and structurally distinct communities.

This paper develops a hybrid modeling strategy that combines data-driven calibration with mechanistic prediction to improve performance prediction of engineered biological systems.

This study combines polymeric micelle-formulated TGFβ receptor inhibitors with Paclitaxel to show consistent anti-tumor effects across multiple TNBC mouse models.

This study identifies two distinct cell populations, p63+Sox2+ and p63-Sox2+, that maintain esophageal tissue homeostasis through different roles in stemness, differentiation, and damage repair.

The paper establishes a stable human cell line as a reference for transcriptomic and proteomic studies, showing consistent results across generations and platforms.

This study shows that MxA GTPase condensates rapidly disassemble and reassemble in response to osmotic changes, maintaining antiviral activity during hypoosmolar conditions.

This study uses synthetic fibrous hydrogels to investigate cell-matrix mechanical interactions and their impact on cellular behavior.

This paper identifies a synthetic glycan, KB39, that increases propionate production by the gut microbiome and reduces cardiometabolic risk factors in mice.

This study examines how parenthood affects gender gaps in academic career achievements, finding that work-family conflict and partner support mediate these gaps.

This study identifies dual-site interactions between Sso2 and Sec3 that drive secretory vesicle fusion in yeast.

This study identifies ORANGE family proteins as regulators of chlorophyll and carotenoid biosynthesis in plants, showing their role in coordinating these pathways for photosynthesis and thermotolerance.

This study identifies and characterizes quiescent stem cells in the mammalian esophageal epithelium using scRNA-seq and DNA methylation profiling in rat models.

The paper develops an ex vivo culture model of kidney podocytes to study injury recovery, revealing mechanosensitive sarcomere-like structures that template synaptopodin.

This study uses sequential CRISPR gene editing in human iPSCs to model clonal evolution in AML, showing progressive dysplasia and identifying therapeutic vulnerabilities.

This study introduces a contraction-reaction-diffusion model that generates circular patterns in embryogenesis by coupling mechanobiological factors with traditional reaction-diffusion equations.

The paper develops a hybrid modeling strategy integrating microbial population dynamics and data-driven approaches to predict bioprocess outcomes with high accuracy.

Nb15-NbH-Nb15, a bispecific nanobody with a heterotrimeric configuration, showed potent neutralization of SARS-CoV-2 in vitro and provided complete protection against infection in hACE2 mice via intranasal administration.

The paper shows that Bt-cotton adoption in China increased the prevalence of a symbiotic virus in the cotton bollworm, enhancing its resistance to Bt-cotton.

This study reports the first systematic analysis of aphid and parasitoid wasp species composition and dynamics in maize fields of Jilin Province, China, over two years.

BR-activated BZR1 suppresses ACO1 activity and expression of ACO1 and ACS1a, reducing ethylene production during pear and apple fruit ripening.

This study uses iTRAQ proteomics to analyze the HCC secretome, identifying CA2 as a diagnostic and prognostic biomarker with potential therapeutic implications.

This paper solves the crystal structure of the giant panda MHC class I complex, revealing unique features of viral peptide presentation in the bear family and providing insights for vaccine design.

This study identifies XPO1 as a vulnerable target in cancer cells using CRISPR-Cas9 screening in KSHV-transformed cells, showing its role in cell proliferation and growth transformation.

This study shows that BMP4 gene therapy reduces myeloma tumor growth in mice but also decreases trabecular bone volume.