Alternative (backdoor) androgen production and masculinization in the human fetus
P. J. O'Shaughnessy, J. P. Antignac, B. Le Bizec, M.-L. Morvan, K. Svecvhnikov, O. Soder, I. Savchuk, A. Monteiro, U. Soffientini, Z. Johnston, M. Bellingham, D. Hough, S. Bhattacharya, N. Walker, P. Filis, P. Fowler
This study identifies androsterone as the main backdoor androgen in human fetal circulation, showing it is synthesized in non-gonadal tissues and critical for masculinization.
bioRxiv · Jul 9, 2018Physiology