Author

U. Specks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. M. Hummel· 2 shared D. E. Jenne· 2 shared D. Emerling· 2 shared G. E. Thompson· 2 shared M. Casal Moura· 2 shared W. H. Robinson· 2 shared W. Volkmuth· 2 shared C. A. Langford· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

A. M. Hummel

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2 papers

Recent·Most cited

Activation of a Latent Epitope Causing Differential Binding of Anti-Neutrophil Cytoplasmic Antibodies to Proteinase 3

M. Casal Moura, G. E. Thompson, D. A. Nelson, L. A. Fussner, A. M. Hummel, D. E. Jenne, D. Emerling, W. Volkmuth, F. C. Fervenza, C. G. M. Kallenberg, C. A. Langford, J. W. McCune, P. A. Merkel, P. A. Monach, P. Seo, , U. Specks

The paper investigates how mutations in PR3 affect PR3-ANCA binding, finding increased binding to a variant with specific mutations.

bioRxiv · Oct 25, 2022Immunology

Remote Activation of a Latent Epitope in an Autoantigen Decoded with Simulated B-Factors

Y.-P. Pang, M. Casal Moura, G. E. Thompson, D. R. Nelson, A. M. Hummel, D. E. Jenne, D. Emerling, W. Volkmuth, W. H. Robinson, U. Specks

The paper shows that remote mutations in PR3 can activate a latent epitope, enabling antibody binding, and suggests using B-factor analysis to design therapeutics targeting autoantigens.

bioRxiv · Aug 10, 2019Biophysics