Author

D. E. Jenne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. M. Hummel· 2 shared D. Emerling· 2 shared G. E. Thompson· 2 shared M. Casal Moura· 2 shared U. Specks· 2 shared W. H. Robinson· 2 shared W. Volkmuth· 2 shared A. Ablasser· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

A. M. Hummel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Activation of a Latent Epitope Causing Differential Binding of Anti-Neutrophil Cytoplasmic Antibodies to Proteinase 3

M. Casal Moura, G. E. Thompson, D. A. Nelson, L. A. Fussner, A. M. Hummel, D. E. Jenne, D. Emerling, W. Volkmuth, F. C. Fervenza, C. G. M. Kallenberg, C. A. Langford, J. W. McCune, P. A. Merkel, P. A. Monach, P. Seo, , U. Specks

The paper investigates how mutations in PR3 affect PR3-ANCA binding, finding increased binding to a variant with specific mutations.

bioRxiv · Oct 25, 2022Immunology

Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing

N. Kessler, S. F. Viehmann, C. Krollmann, K. Mai, K. M. Kirschner, H. Luksch, P. Kotagiri, A. M. C. Boehner, D. Huugen, C. C. de Oliveira Mann, S. Otten, S. A. I. Weiss, T. Zillinger, K. Dobrikova, D. E. Jenne, , N. Garbi

This study identifies cGAS/STING/IFN-mediated nucleic acid sensing by monocyte-derived macrophages as a driver of severe pulmonary vasculitis and shows that targeting this pathway reduces disease severity.

bioRxiv · May 30, 2022Immunology

Tumor-secreted versican co-opts myeloid IKKβ during metastasis

M. Spella, A. S. Lamort, M. Vreka, A. Marazioti, I. Lilis, G. Ntaliarda, G. Skiadas, E. Bouloukou, G. A. Giotopoulou, M. A. Pepe, S. A. Weiss, A. Petrera, S. M. Hauck, I. Koch, M. Lindner, , G. T. Stathopoulos

This study identifies tumor-secreted versican as a driver of myeloid IKKβ activation during metastasis, showing its role in promoting inflammation and metastasis through IL-1β release.

bioRxiv · May 20, 2021 · PreprintCancer Biology

Remote Activation of a Latent Epitope in an Autoantigen Decoded with Simulated B-Factors

Y.-P. Pang, M. Casal Moura, G. E. Thompson, D. R. Nelson, A. M. Hummel, D. E. Jenne, D. Emerling, W. Volkmuth, W. H. Robinson, U. Specks

The paper shows that remote mutations in PR3 can activate a latent epitope, enabling antibody binding, and suggests using B-factor analysis to design therapeutics targeting autoantigens.

bioRxiv · Aug 10, 2019Biophysics