Cancer BiologyCancer ResearchPeer-reviewed
MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression
S. G. Rudd, H. Gad, N. Amaral…·T. Helleday
The paper shows that MTH1 inhibitor TH588 causes genomic 8-oxodG accumulation during mitosis, leading to mitotic arrest and cytotoxicity.
DOI 10.1158/0008-5472.can-19-0883