Polyketide synthase 12 is an in vivo essential source of novel mycolyl lipids in Mycobacterium tuberculosis
Gregory H. Babunovic, Sanne van der Niet, Marco Túlio Pardini Gontijo, Katherine Abrahams, Rong Sun, Kiranmai Bhatt, Ella Meirav, Catherine Vilchèze, David C Young, Lara Rosbach, Ignė Kanopaitė, Oyinda O Adefisayo, Kirsten M. Smith, Ana M. Xet-Mull, V Grace Dellinger, , David Branch Moody
The paper identifies pks12 as an in vivo essential gene in Mtb by combining genomic, metabolomic, and phenotypic analyses, revealing its role in mycolyl lipid synthesis and host-pathogen interface structure.
bioRxiv · Sep 25, 2026 · PreprintMicrobiology