Author

V. Chavez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

A. F. Yu· 1 shared A. M. Schmitt· 1 shared A. Piersigilli· 1 shared A. Shamseddine· 1 shared A. T. Chan· 1 shared C. T. Dang· 1 shared D. Essegian· 1 shared J. E. Liu· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

A. F. Yu

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Author profile →

2 papers

Recent·Most cited

Innate immune signaling drives late cardiac toxicity following DNA damaging cancer therapies

A. Shamseddine, S. Patel, V. Chavez, M. Adnan, M. Di Bona, J. Li, C. T. Dang, L. V. Ramanathan, K. C. Oeffinger, J. E. Liu, R. M. Steingart, A. Piersigilli, N. D. Socci, A. T. Chan, A. F. Yu, , A. M. Schmitt

This study identifies cGAS-STING signaling as a driver of late cardiac toxicity after DNA-damaging cancer therapies and shows that targeting this pathway can mitigate cardiotoxicity.

Journal of Experimental Medicine · Dec 19, 2022Peer-reviewedImmunology

AI-Assisted Chemical Probe Discovery for the Understudied Calcium-Calmodulin Dependent Kinase, PNCK

D. Essegian, V. Chavez, R. Khurshid, J. R. Merchan, S. C. Schürer

The paper develops small-molecule inhibitors for PNCK using homology modeling, machine learning, virtual screening, and molecular dynamics to enable further study of its role in cancer.

bioRxiv · Jun 1, 2022Pharmacology & Toxicology